ABSTRACT
Premature neonates are at risk for severe anemia and erythropoietin is the most important hormone in erythropoiesis. The aim of this study was to evaluate the influence of oral recombinant human erythropoietin [rhEPO] in proving erythropoiesis in neonates. This was a randomized clinical trial study. Thirty neonates were enrolled from September 2007 to September 2008. The first group received oral rhEPO and Fe and the second, subcutaneous rhEPO and Fe. The patients' Hb, HCT and the need to blood transfusion were recorded. We included all infants with gestational age <34 weeks, birth weight <1500 gr, without respiratory distress [O[2] Saturation> 85%, FiO[2] of 30%], full feeding tolerance so that oral Fe can be administrated. In first group [oral=PO], 65% of neonates were female and 35% were male, mean weight was 1140 g and mean GA was 32.6 weeks. In the second group [subcutaneous=SC], 42% were female and 58% were male. The mean weight was 1245 g and mean GA was 31.2 weeks and this was not statistically significant. In the first group, the mean Hb and HCT were 9.7 +/- 1.9 and 29.6 +/- 5.9 g/dl. In the second group, the figures were 12.5 +/- 1.7 and 38.8 +/- 5.1 which were statistically significant. There was no difference in the weight gain between two groups. In the first group, 3 neonates [20%] and in the second one, 1 neonate [15%] needed blood transfusion. rhEPO administration either PO or SC could prevent anemia of prematurity but SC rout was more effective
Subject(s)
Humans , Female , Male , Anemia/drug therapy , Infant, Premature , Recombinant Proteins , Erythropoietin/administration & dosageABSTRACT
Background and Purpose: Bili-Check is a simple method used to provide a rapid pain-free and noninvasive transcutaneous estimation of total serum bilirubin. The present study was conducted to compare estimates of serum bilirubin using Bili-Check [TCB] with total serum bilirubin [TSB] values determined in a clinical laboratory
Methods and Materials: This is a dehlive analytical cross-sectional study conducted in Ghaem Hospital NICU from September 2008 to March 2008. With a confidence interval of 95% and test power of 80% 109 neonates were selected through convenient non-randomized sampling as the study sample. TSB was determined in a clinical laboratory using the diazo with photometric method. Then within 10 minutes transcutaneous measurements were performed via Bili-Check. Data analysis was done in SPSS11.5 using correlation coefficient
Results: From 109 neonates included in the study 75 were male [68.8%] and 34 female [31.2%] with an age range of 1 to 26 days. Mean serum Bilirubin was 12.979 and TCB estimate was 12.219. Laboratory findings highly correlated with the results of TCB [r=0.766] [P=0.0001]
Conclusion: Bili-Check has the sufficient adequacy as the measurement and observation device for neonates and can replace serum bilirubinometry in laboratory fro Icteric neonates